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Article

Function of Macrophages in Disease: Current Understanding on Molecular Mechanisms.

Frontiers in immunology - 1 Jan 2021

Zhang Chunye, Yang Ming, Ericsson Aaron C

Abstract excerpt

Tissue-resident macrophages (TRMs) are heterogeneous populations originating either from monocytes or embryonic progenitors, and distribute in lymphoid and non-lymphoid tissues. TRMs play diverse roles in many physiological processes, including metabolic function, clearance of cellular debris, and tissue remodeling and defense. Macrophages can be polarized to different functional phenotypes depending on their...

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Identifiers

PMID: 33763066
DOI: 10.3389/fimmu.2021.620510
PMCID: PMC7982479

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