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Article

TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.

The Journal of biological chemistry - 10 Aug 2012

Scheer Elisabeth, Delbac Frédéric, Tora Laszlo, Moras Dino, Romier Christophe

Abstract excerpt

The general transcription factor TFIID recognizes specifically the core promoter of genes transcribed by eukaryotic RNA polymerase II, nucleating the assembly of the preinitiation complex at the transcription start site. However, the understanding in molecular terms of TFIID assembly and function remains poorly understood. Histone fold motifs have been shown to be extremely important for the heterodimerization of...

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Source

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Identifiers

PMID: 22696218
DOI: 10.1074/jbc.M112.379206
PMCID: PMC3431708

Genes

TAF6
TAF9
TAF5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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TFIID TAF6-TAF9 complex formation involves the HEAT repeat-containing C-terminal domain of TAF6 and is modulated by TAF5 protein.PMID 22696218Read ↗

Mutational analysis of TAF6 revealed the essential requirement of the histone-fold domain and the HEAT repeat domain for transcriptional activation.Semantic proximity Read ↗

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A novel histone fold domain-containing protein that replaces TAF6 in Drosophila SAGA is required for SAGA-dependent gene expression.Semantic proximity Read ↗

A histone fold TAF octamer within the yeast TFIID transcriptional coactivator.Semantic proximity Read ↗

The structure of an Iws1/Spt6 complex reveals an interaction domain conserved in TFIIS, Elongin A and Med26.Semantic proximity Read ↗

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Genome-wide localization analysis of a complete set of Tafs reveals a specific effect of the taf1 mutation on Taf2 occupancy and provides indirect evidence for different TFIID conformations at different promoters.Semantic proximity Read ↗

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