Article

Wild-type and mutated ß-catenin differently repress <i>RND3/RHOE</i> expression in hepatocellular carcinoma

2025-10-16

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background & Aims</h4> Tumor development and progression are mainly driven by oncogenic mutations but are also regulated by physical factors, such as applied forces or microenvironment stiffness. Through its structural and transcriptional functions, ßcatenin is a key factor that acts on both aspects to promote liver tumorigenesis, leading to hepatocellular carcinoma (HCC) development. Howev...

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Literature Corpus work: c0407996-2b0b-5bca-8168-fcf6e0b3abe7
DOI: 10.1101/2025.10.16.682743

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