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The RND1 Small GTPase: Main Functions and Emerging Role in Oncogenesis

24 Jul 2019

Abstract excerpt

The Rho GTPase family can be classified into classic and atypical members. Classic members cycle between an inactive Guanosine DiPhosphate -bound state and an active Guanosine TriPhosphate-bound state. Atypical Rho GTPases, such as RND1, are predominantly in an active GTP-bound conformation. The role of classic members in oncogenesis has been the subject of numerous studies, while that of atypical members has...

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PMID: 31344837
DOI: 10.3390/ijms20153612

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