Article

NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner

2020-03-23

Abstract excerpt

<h4>Background: </h4> Hepatocellular carcinoma is the third top cause of cancer-related mortalities worldwide. The prognosis of HCC patients remains poor due to rapid progression and high incidence of tumor recurrence. Nicastrin (NCSTN), a core subunit of γ-Secretase, has been reported to play a vital role in tumor progression. However, no study till now has revealed its role in HCC. Methods The expression of NCST...

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Literature Corpus work: e7a42035-017d-50b1-a43e-491c86a0e9e1
DOI: 10.21203/rs.3.rs-18622/v1

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