Article

TGFβ-induced long non-coding RNA <i>LINC00313</i> activates Wnt signalling and promotes cholangiocarcinoma

2022-09-29

Abstract excerpt

Cholangiocarcinoma (CCA) is a poor prognosis liver cancer characterized by high aggressiveness and resistance to therapy. Long non-coding RNAs (lncRNAs) and signals imposed by oncogenic pathways, such as transforming growth factor β (TGFβ), contribute to cholangiocarcinogenesis. Here, we identified LINC00313 lncRNA as a novel target of TGFβ signalling in CCA cells. TGFβ induced LINC00313 expression in a TβRI/Smad-...

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Literature Corpus work: 43f46f54-0c67-5b54-99c0-ee611d54b366
DOI: 10.1101/2022.09.28.509889

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