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Article

RHBDD1 promotes colorectal cancer metastasis through the Wnt signaling pathway and its downstream target ZEB1.

Journal of experimental & clinical cancer research : CR - 9 Feb 2018

Zhang Mengmeng, Miao Fei, Huang Rong, Liu Wenjie, Zhao Yuechao, Jiao Tao, Lu Yalan, Wu Fan, Wang Xiaojuan, Wang Han, Zhao Hong, Ju Hongge, Miao Shiying, Wang Linfang, Song Wei

Abstract excerpt

BACKGROUND: 40-50% of colorectal cancer (CRC) patients develop metastatic disease; the presence of metastasis hinders the effective treatment of cancer through surgery, chemotherapy and radiotherapy, which makes 5-year survival rate extremely low; therefore, studying CRC metastasis is crucial for disease therapy. In the present study, we investigated the role of rhomboid domain containing 1 (RHBDD1) in tumor...

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Source

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Identifiers

PMID: 29426364
DOI: 10.1186/s13046-018-0687-5
PMCID: PMC5807852

Genes

RHBDD1
ZEB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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