Article

Next-generation all-in-one CRISPR/Cas9 multiply-edited CD30CAR-T cells: Potency despite risk of translocations

2026-04-07

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Chimeric antigen receptor (CAR)-T cells are therapeutic breakthroughs against advanced non-Hodgkin lymphomas and myelomas. On the other hand, no CAR-T cell product has been so far clinically approved for therapy of Hodgkin Lymphoma (HL), T cell lymphoma (TCL), or Epstein-Barr-Virus (EBV)-associated lymphoproliferative diseases (EBV-LPDs). CD30 (TNFRSF8) is co...

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Literature Corpus work: d6b92170-2d92-5238-bd40-8dfb8e38891b
DOI: 10.21203/rs.3.rs-8902221/v1

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