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Article

The cancer cells-of-origin in the gastrointestinal tract: progenitors revisited.

Carcinogenesis - 1 Aug 2015

Lamprecht Sergio, Fich Alexander

Abstract excerpt

A prominent model of tumor progression posits that normal self-renewing and multipotent stem cells(SCs) are the initial target of transformation. This view has been robustly challenged by the recurring observation that transit-amplifying cells and differentiated progenitors can initiate neoplasia outside the SC zone thus qualifying as cancer cells-of-origin. The emerging concept is that a cancer SC and a cancer...

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Share to Adenomatous Polyposis Coli Protein
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Identifiers

PMID: 26116624
DOI: 10.1093/carcin/bgv095

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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