Article

HSBP7 Rescue of a Titin Cardiomyopathy Identified by Morphological Profiling

2024-07-08

Abstract excerpt

<title>Abstract</title> <p>Dilated cardiomyopathy (DCM), a genetic heart disease, is a major contributor to heart failure and cardiac transplantation. Of the many genes underlying DCM, the most common cause is loss of function mutations in the sarcomeric protein titin. In disease, alterations in cardiomyocyte (CM) contractile function are accompanied by morphologic changes. Thus, understanding how genetic and env...

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Literature Corpus work: c017dbae-0abd-5d9f-8f6c-0855540b2709
DOI: 10.21203/rs.3.rs-4558927/v1

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