Proteo-transcriptomics and morphometrics of teleost cardiac cells define regulatory networks and exercise-induced cardiomyocyte hypertrophy and hyperplasia

Abstract excerpt

<h4>SUMMARY</h4> Zebrafish and medaka are powerful cardiovascular models, yet cellular and molecular investigations of adult heart cells have been constrained by suboptimal dissociation and characterization methods. To overcome these barriers, we developed a physiological-temperature workflow that generates high-yield, viable single-cell suspensions for FACS, imaging, and low-input molecular profiling. Using tran...

Topics

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• Atherosclerosis and Cardiovascular Diseases
• Cancer-related molecular mechanisms research
• Cardiac Fibrosis and Remodeling
• Cardiomyopathy and Myosin Studies
• Cardiovascular Effects of Exercise
• Congenital heart defects research
• Coronary Artery Anomalies
• Single-cell and spatial transcriptomics

Identifiers and source

Literature Corpus work

b52e06ad-629c-5cf2-a1f2-0b4dd1a0bd1f

DOI

10.64898/2026.01.11.698907