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Landscape of transcriptomic interactions between breast cancer and its microenvironment

15 Jul 2019

Abstract excerpt

Solid tumours comprise mixtures of tumour cells (TCs) and tumour-adjacent cells (TACs), and the intricate interconnections between these diverse populations shape the tumour's microenvironment. Despite this complexity, clinical genomic profiling is typically performed from bulk samples, without distinguishing TCs from TACs. To better understand TC-TAC interactions, we computationally distinguish their...

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PMID: 31308365
DOI: 10.1038/s41467-019-10929-z

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