Article

Pathogenic strains of a gut commensal drive systemic platelet activation and thromboinflammation in lupus nephritis

2025-06-24

Abstract excerpt

Imbalances in the gut microbiome have been linked to increased intestinal permeability and disease flares in systemic lupus erythematosus (SLE). Our study revealed that patients with flares of lupus nephritis (LN) and intestinal expansions of the anaerobic commensal, Ruminococcus gnavus (RG), displayed whole blood transcriptome profiles indicative of platelet, neutrophil, and myeloid cell activation, a profile re...

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Literature Corpus work: bfde44c3-62c9-5bfb-bc48-3cfc72c782ec
DOI: 10.1101/2025.06.20.641288

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