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Outgrowth of Escherichia is susceptible to aggravation of systemic lupus erythematosus

7 Nov 2024

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is linked to host gut dysbiosis. Here we performed faecal gut microbiome sequencing to investigate SLE-pathogenic gut microbes and their potential mechanisms. METHODS: There were 134 healthy controls (HCs) and 114 SLE cases for 16 S ribosomal RNA (rRNA) sequencing and 97 HCs and 124 SLE cases for shotgun metagenomics. Faecal microbial changes and associations with...

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PMID: 39511594
DOI: 10.1186/s13075-024-03413-7

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