Article

Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons

2020-09-10

Abstract excerpt

The human genome contains vast genetic diversity in the form of naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein that suppresses synaptic plasticity in dendritic spines of hippocampal neurons. RGS14 also is a nucleocytoplasmic shuttling protein, suggesting that balanced nuclear import/export a...

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Literature Corpus work: bf92a148-af6f-5275-9679-a8fdd2b5353c
DOI: 10.1101/2020.09.10.289991

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