Article
Loss-of-function mutation in PRMT9 causes abnormal synapse development by dysregulation of RNA alternative splicing.
Nature communications - 1 Apr 2024
Shen Lei, Ma Xiaokuang, Wang Yuanyuan, Wang Zhihao, Zhang Yi, Pham Hoang Quoc Hai, Tao Xiaoqun, Cui Yuehua, Wei Jing, Lin Dimitri, Abeywanada Tharindumala, Hardikar Swanand, Halabelian Levon, Smith Noah, Chen Taiping, Barsyte-Lovejoy Dalia, Qiu Shenfeng, Xing Yi, Yang Yanzhong
Abstract excerpt
Protein arginine methyltransferase 9 (PRMT9) is a recently identified member of the PRMT family, yet its biological function remains largely unknown. Here, by characterizing an intellectual disability associated PRMT9 mutation (G189R) and establishing a Prmt9 conditional knockout (cKO) mouse model, we uncover an important function of PRMT9 in neuronal development. The G189R mutation abolishes PRMT9...
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