Article

The microcephaly-associated protein YIPF5 differentially regulates ER-export

2025-06-11

Abstract excerpt

YIPF5 is a small ER-membrane protein implicated in ER-Golgi transport. Mutations in YIPF5 cause MEDS2 (microcephaly with simplified gyral pattern, epilepsy, and neonatal diabetes syndrome), a fatal disorder manifesting in early childhood. We demonstrate that YIPF5 is involved in ER export of a subset of proteins, including cargoes of the ER-export receptor SURF4, with which it directly interacts. In YIPF5 knockout...

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Identifiers and source

Literature Corpus work: 8908cb09-bcec-5d03-8db8-09ab36874837
DOI: 10.1101/2025.06.11.659036

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