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Article

Human genetic variants disrupt RGS14 nuclear shuttling and regulation of LTP in hippocampal neurons.

The Journal of biological chemistry - 1 Jan 2000

Squires Katherine E, Gerber Kyle J, Tillman Matthew C, Lustberg Daniel J, Montañez-Miranda Carolina, Zhao Meilan, Ramineni Suneela, Scharer Christopher D, Saha Ramendra N, Shu Feng-Jue, Schroeder Jason P, Ortlund Eric A, Weinshenker David, Dudek Serena M, Hepler John R

Abstract excerpt

The human genome contains vast genetic diversity as naturally occurring coding variants, yet the impact of these variants on protein function and physiology is poorly understood. RGS14 is a multifunctional signaling protein that suppresses synaptic plasticity in dendritic spines of hippocampal neurons. RGS14 also is a nucleocytoplasmic shuttling protein, suggesting that balanced nuclear import/export and...

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Identifiers

PMID: 33410399
DOI: 10.1074/jbc.RA120.016009
PMCID: PMC7949046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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