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Article

RNA Misprocessing in C9orf72-Linked Neurodegeneration

11 Jul 2017

Abstract excerpt

A large GGGGCC hexanucleotide repeat expansion in the first intron or promoter region of the C9orf72 gene is the most common genetic cause of familial and sporadic Amyotrophic lateral sclerosis (ALS), a devastating degenerative disease of motor neurons, and of Frontotemporal Dementia (FTD), the second most common form of presenile dementia after Alzheimer’s disease. C9orf72-associated ALS/FTD is a multifaceted...

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Identifiers

PMID: 28744202
DOI: 10.3389/fncel.2017.00195

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