Article

Spatially resolved transcriptomics reveals gene signatures underlying the vulnerability of human middle temporal gyrus in Alzheimer's disease

2021-09-10

Abstract excerpt

<title>Abstract</title> <p>Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's disease (AD); however, little is known about the molecular mechanisms underlying this regional vulnerability. Here we use the 10x Visium platform to define the spatial topography of gene expression in the MTG from both early AD and control cases. We identify differentially expressed genes (DEGs) and enri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8ff0bb15-cebc-5a6d-bc9b-4dfd858e0e46
DOI: 10.21203/rs.3.rs-855234/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatially resolved transcriptomics reveals gene signatures underlying the vulnerability of human middle temporal gyrus in Alzheimer's diseaseDOI 10.21203/rs.3.rs-855234/v1Read

Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer’s diseaseSemantic proximity Read

Spatially resolved transcriptomics reveals unique gene signatures associated with human temporal cortical architecture and Alzheimer’s pathologySemantic proximity Read

Influence of Alzheimer’s disease related neuropathology on local microenvironment gene expression in the human inferior temporal cortexSemantic proximity Read

Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer’s diseaseSemantic proximity Read

Spatial transcriptomic patterns underlying regional vulnerability to amyloid-β and tau pathologies and their relationships to cognitive dysfunction in Alzheimer’s diseaseSemantic proximity Read

Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer’s disease: transcriptomics combined with machine learning analysisSemantic proximity Read

Transcriptomic profiling of the middle temporal gyrus reveals differential glial/neuronal dysregulation across Alzheimer’s disease and agingSemantic proximity Read

Systematic Analysis of Biological Processes Reveals Gene Co-expression Modules Driving Pathway Dysregulation in Alzheimer’s DiseaseSemantic proximity Read

Genes and pathways underlying regional and cell type changes in Alzheimer's diseaseSemantic proximity Read

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.Semantic proximity Read

Exploring the selective vulnerability in Alzheimer disease using tissue specific variant analysis.Semantic proximity Read

Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1Semantic proximity Read