Article

GLA-3 Mediates Stress Response in <i>Caenorhabditis elegans</i> Germ Cells: A key role of the Tristetraprolin (TTP) Family

2024-10-03

Abstract excerpt

Tristetraprolin or TTP is an RNA-binding protein that possesses two CCCH-like zinc-finger domains that bind AU-rich elements to promote their degradation. One of its targets is the mRNA of tumor necrosis factor alpha (TNF-α). When TTP is absence, the TNF-α factor accumulates causing severe, generalized inflammation in knockout mice. TTP is also considered a tumor suppressor protein because regulates the expression...

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Literature Corpus work: bf593507-131e-5f99-9890-9a1fc98cfe03
DOI: 10.1101/2024.10.01.616206

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