Article

An AI-Driven Framework for Discovery of BACE1 Inhibitors for Alzheimer’s Disease

2024-05-15

Abstract excerpt

Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder that affects over 51 million individuals globally. The β -secretase (BACE1) enzyme is responsible for the production of amyloid beta (A β ) plaques in the brain. The accumulation of A β plaques leads to neuronal death and the impairment of cognitive abilities, both of which are fundamental symptoms of AD. Thus, BACE1 has emerged as a promising...

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Literature Corpus work: b291c75c-2f43-5b72-a028-735fb29d1c98
DOI: 10.1101/2024.05.15.594361

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