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Article

On the linkage of thermodynamics and pathogenicity.

Current opinion in structural biology - 1 Jun 2023

Pandey Preeti, Ghimire Sanjeev, Wu Bohua, Alexov Emil

Abstract excerpt

This review outlines the effect of disease-causing mutations on proteins' thermodynamics. Two major thermodynamics quantities, which are essential for structural integrity, the folding and binding free energy changes caused by missense mutations, are considered. It is emphasized that disease effects in case of complex diseases may originate from several mutations over several genes, while monogenic diseases are...

Topics

Virulence
Protein Folding
Mutation
Proteins
Thermodynamics

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36965249
DOI: 10.1016/j.sbi.2023.102572
PMCID: PMC10239362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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