Article

Most monogenic disorders are caused by mutations altering protein folding free energy

2023-10-19

Abstract excerpt

Revealing the molecular effect that pathogenic missense mutations cause on the corresponding protein is crucial for developing therapeutic solutions. This is especially important for monogenic diseases since, for most of them, there is no treatment available, while typically, the treatment should be provided in the early development stages. This requires fast, targeted drug development at a low cost. Here, we repo...

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Literature Corpus work: ffe5dd18-9471-50c7-9a89-b4e99076f4e5
DOI: 10.21203/rs.3.rs-3442589/v1

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