Article

A dominant CIDEC variant segregates with familial obesity by increasing lipid droplet size in adipocytes

2025-07-29

Abstract excerpt

Adipose tissue dysfunction in obesity is a major global public health risk, contributing to insulin resistance and chronic diseases such as diabetes and cardiovascular disorders. Here, we identify a dominant c.37A>G p.(Arg13Gly) variant in the long isoform of CIDEC (CIDEC-L), a key regulator of lipid droplet (LD) size, as the underlying cause of familial obesity. Affected individuals display marked subcutaneous fa...

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Literature Corpus work: 9e1f800a-89b1-5b5d-bf33-a978a8a6c22d
DOI: 10.1101/2025.07.28.25332029

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