Article
Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.
Nature communications - 1 Jan 2013
Sun Zhiqi, Gong Jingyi, Wu Han, Xu Wenyi, Wu Lizhen, Xu Dijin, Gao Jinlan, Wu Jia-Wei, Yang Hongyuan, Yang Maojun, Li Peng
Abstract excerpt
Mature white adipocytes contain a characteristic unilocular lipid droplet. However, the molecular mechanisms underlying unilocular lipid droplet formation are poorly understood. We previously showed that Fsp27, an adipocyte-specific lipid droplet-associated protein, promotes lipid droplet growth by initiating lipid exchange and transfer. Here, we identify Perilipin1 (Plin1), another adipocyte-specific lipid...
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