Article

MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repair

2026-03-04

Abstract excerpt

<h4>ABSTRACT</h4> The base excision repair (BER) glycosylase MUTYH initiates repair of 8-oxo-7,8-dihydroguanine (OG): adenine (A) mispairs to prevent G to T transversion mutations. Inherited biallelic mutations in MUTYH are correlated with the cancer pre-disposition syndrome MUTYH -associated polyposis (MAP) and contribute to an increased lifetime risk of colorectal cancer. Over 1,000 germline and somatic MUTY...

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Literature Corpus work: bf29017f-3be6-573e-a8cd-4c443d0084ab
DOI: 10.64898/2026.03.03.709415

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