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Article

Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants.

Nucleic acids research - 20 Mar 2025

Vasquez Carlos A, Osgood Nicola R B, Zepeda Marcanthony U, Sandel Dominika K, Cowan Quinn T, Peiris Malalage N, Donoghue Daniel J, Komor Alexis C

Abstract excerpt

Functional characterization of genetic variants has the potential to advance the field of precision medicine by enhancing the efficacy of current therapies and accelerating the development of new approaches to combat genetic diseases. MUTYH is a DNA repair enzyme that recognizes and repairs oxidatively damaged guanines [8-oxoguanine (8-oxoG)] mispaired with adenines (8-oxoG·A). While some mutations in the MUTYH...

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Source

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Identifiers

PMID: 40156857
DOI: 10.1093/nar/gkaf037
PMCID: PMC11952967

Genes

MUTYH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants.PMID 40156857Read ↗

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