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Article

MUTYH Cancer-Associated Variants Within the Interdomain Connector Differentially Impact Glycosylase Activity and Cellular DNA Repair.

Chembiochem : a European journal of chemical biology - 14 Jul 2026

Khuu Cindy, Malek Melody, Conlon Savannah G, Wadey Geoffrey P, Trasviña-Arenas Carlos H, David Sheila S

Abstract excerpt

The base excision repair (BER) glycosylase MUTYH initiates repair of 8-oxo-7,8-dihydroguanine (OG): adenine (A) mispairs to prevent G to T transversion mutations. Inherited biallelic mutations in MUTYH are correlated with the cancer predisposition syndrome MUTYH-associated polyposis (MAP) and contribute to an increased lifetime risk of colorectal cancer. Over 1000 germline and somatic MUTYH variants have been...

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Identifiers

PMID: 42427202
DOI: 10.1002/cbic.70412
PMCID: PMC13351819

Genes

MUTYH

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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MUTYH Cancer-Associated Variants Within the Interdomain Connector Differentially Impact Glycosylase Activity and Cellular DNA Repair.PMID 42427202Read ↗

MUTYH cancer-associated variants within the interdomain connector differentially impact glycosylase activity and cellular DNA repairSemantic proximity Read ↗

The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.Semantic proximity Read ↗

Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.Semantic proximity Read ↗

Structure of the mammalian adenine DNA glycosylase MUTYH: insights into the base excision repair pathway and cancer.Semantic proximity Read ↗

Role of MUTYH in human cancer.Semantic proximity Read ↗

MUTYH-associated polyposis--from defect in base excision repair to clinical genetic testing.Semantic proximity Read ↗

MUTYH DNA glycosylase: the rationale for removing undamaged bases from the DNASemantic proximity Read ↗

A Specific Mutational Signature Associated with DNA 8-Oxoguanine Persistence in MUTYH-defective Colorectal Cancer.Semantic proximity Read ↗

Pan-Cancer Interrogation of MUTYH Variants Reveals Biallelic Inactivation and Defective Base Excision Repair Across a Spectrum of Solid Tumors.Semantic proximity Read ↗

MUTYH-Associated Polyposis: The Irish Experience>.Semantic proximity Read ↗

Understanding the role of the Q338H MUTYH variant in oxidative damage repair.Semantic proximity Read ↗

Precision genome editing and in-cell measurements of oxidative DNA damage repair enable functional and mechanistic characterization of cancer-associated MUTYH variants.Semantic proximity Read ↗

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