Article

Structural Connectivity Between the Zinc Linchpin Motif, the [4Fe-4S] cluster, and the active site orchestrates DNA repair in MUTYH

2026-05-30

Abstract excerpt

<h4>ABSTRACT</h4> The DNA glycosylase MUTYH protects genomic integrity by excising adenine mispaired with 8-oxoguanine (OG), which initiates base excision repair (BER). The [4Fe-4S] cluster DNA binding domain and Zn linchpin motif of MUTYH are hotspots for inherited cancer associated variants (CAVs) highlighting their critical functions in DNA repair. Here, we present three full-length human MUTYH crystal structu...

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Literature Corpus work: 8589cfbb-1727-5f33-8527-50a0bd765a27
DOI: 10.64898/2026.05.27.728240

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