<i>NR1H3</i> p.Arg415Gln Is Not Associated To Multiple Sclerosis Risk

Abstract excerpt

A recent study by Wang et al claims the low-frequency variant NR1H3 p.Arg415Gln is pathological for multiple sclerosis and determines a patient’s likelihood of primary progressive disease. We sought to replicate this finding in the International MS Genetics Consortium (IMSGC) patient collection, which is 13-fold larger than the collection of Wang et al , but we find no evidence that this variant is associated e...

Topics

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• Gene Expression
• Genome-Wide Association Study
• Liver X Receptors
• Multiple Sclerosis
• Mutation
• Polymorphism, Single Nucleotide
• Risk
• White People

Identifiers and source

Literature Corpus work

bf2846e8-760e-5ee6-bd05-85ff73e6f7a9

DOI

10.1101/061366