Article
Case-Control Studies Are Not Familial Studies.
Neuron - 19 Oct 2016
Wang Zhe, Sadovnick A Dessa, Traboulsee Anthony L, Ross Jay P, Bernales Cecily Q, Encarnacion Mary, Yee Irene M, de Lemos Madonna, Greenwood Talitha, Lee Joshua D, Wright Galen, Ross Colin J, Zhang Si, Song Weihong, Vilariño-Güell Carles
Abstract excerpt
Identifying rare genetic variants that drive the onset of disease is challenging, even before considering the additional genetic and environmental influences that likely exist in complex diseases. We recently published a study proposing a rare variant in the NR1H3 gene (p.R415Q, rs61731956) as responsible for the onset of multiple sclerosis (MS) in two multi-incident families (Wang et al., 2016). This publication...
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