Article

GSA: An Independent Development Algorithm for Calling Copy Number and Detecting Homologous Recombination Deficiency (HRD) from Target Capture Sequencing

2021-08-03

Abstract excerpt

<h4>Background</h4> The gain or loss of large chromosomal regions or even whole chromosomes is termed as genomic scarring and can be observed as copy number variations resulting from the failure of DNA damage repair. <h4>Results</h4> In this study, a new algorithm called Genomic Scar Analysis (GSA) has developed and validated to calculate homologous recombination deficiency (HRD) score. The two critical submodul...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bf0a26a9-fdb9-5a8e-8670-c5c3f9ed737a
DOI: 10.1101/2021.08.02.454110

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GSA: An Independent Development Algorithm for Calling Copy Number and Detecting Homologous Recombination Deficiency (HRD) from Target Capture SequencingDOI 10.1101/2021.08.02.454110Read

GSA: an independent development algorithm for calling copy number and detecting homologous recombination deficiency (HRD) from target capture sequencingSemantic proximity Read

DirectHRD enables sensitive scar-based classification of homologous recombination deficiencySemantic proximity Read

ShallowHRD: detection of homologous recombination deficiency from shallow whole genome sequencingSemantic proximity Read

Copy number alteration features in pan-cancer homologous recombination deficiency prediction and biologySemantic proximity Read

Genomic Scar Score: A robust model predicting homologous recombination deficiency based on genomic instabilitySemantic proximity Read

AcornHRD: an HRD algorithm highly associated with anthracycline-based neoadjuvant chemotherapy in breast cancer in ChinaSemantic proximity Read

Scuphr: A probabilistic framework for cell lineage tree reconstructionSemantic proximity Read

Improved detection of homologous recombination deficiency in Chinese patients with ovarian cancer: a novel non-exonic single-nucleotide polymorphism-based next-generation sequencing panel.Semantic proximity Read

RediScore: Prospective validation of a pipeline for homologous recombination deficiency analysisSemantic proximity Read

Recent Advances in Genomic Approaches for the Detection of Homologous Recombination Deficiency.Semantic proximity Read

AcornHRD: an HRD algorithm which was highly associated with anthracycline-based neoadjuvant chemotherapy in Chinese breast cancerSemantic proximity Read

Homologous recombination deficiency (HRD) testing landscape: clinical applications and technical validation for routine diagnosticsSemantic proximity Read