Identifiability of phenotypic adaptation from low-cell-count experiments and a stochastic model.

Abstract excerpt

Phenotypic plasticity contributes significantly to treatment failure in many cancers. Despite the increased prevalence of experimental studies that interrogate this phenomenon, there remains a lack of applicable quantitative tools to characterise data, and importantly to distinguish between resistance as a discrete phenotype and a continuous distribution of phenotypes. To address this, we develop a stochastic...

Topics

• Stochastic Processes
• Phenotype
• Humans
• Models, Biological
• Cell Count
• Adaptation, Physiological