Article

S125: NON-GENETIC RESISTANCE TO MENIN INHIBITION IN AML IS REVERSIBLE BY PERTURBATION OF KAT6A

2023-08-01

Abstract excerpt

Background: A novel class of small-molecule inhibitors of the Menin-MLL1 interaction are efficient in pre-clinical models and show remarkable efficacy in clinical trials in relapsed and therapy refractory MLL-rearranged and NPM1 mutant AML by disrupting the oncogenic Menin-MLL1-complex on chromatin. Targeting Menin leads to profound epigenetic reprogramming of leukemia cells resulting in terminal myeloid different...

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Literature Corpus work: 2e8fde68-b325-5b7a-a799-4d44cd502ae8
DOI: 10.1097/01.hs9.0000967412.62331.23

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