The life-and-death struggle between the complement system and pathogens: Mechanisms of elimination, evasion tactics, and translational potential

Abstract excerpt

The complement system, along with its intricate network, constitutes a vital component of the innate immune response, playing a pivotal role in defending the host against invading pathogens. While it is essential for maintaining immune homeostasis, dysregulation of this system can lead to significant pathological consequences: deficiencies in complement components increase susceptibility to infections, whereas...