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Bacteria under stress by complement and coagulation

25 Jul 2014

Abstract excerpt

The complement and coagulation systems are two related protein cascades in plasma that serve important roles in host defense and hemostasis, respectively. Complement activation on bacteria supports cellular immune responses and leads to direct killing of bacteria via assembly of the Membrane Attack Complex (MAC). Recent studies have indicated that the coagulation system also contributes to mammalian innate...

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PMID: 25065463
DOI: 10.1111/1574-6976.12080

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