Article

A rad50 germline mutation induces the ataxia-telangiectasia phenotype in a transparent medaka model

2022-09-29

Abstract excerpt

Mutations in the MRN-ATM pathway-related genes cause MRN-related diseases and ataxia-telangiectasia. However, the effect of RAD50 mutations on these diseases remains unclear. To understand the function of RAD50 in the pathogenesis of ataxia-telangiectasia, we adopted a medaka rad50 mutant model. A two-base deletion in the rad50 gene was introduced into transparent STIII medaka using the CRISPR/Cas9 system. Results...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: beadaf3d-8356-5ff7-a51f-052099dc7240
DOI: 10.21203/rs.3.rs-2103020/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 11 closest

A rad50 germline mutation induces the ataxia-telangiectasia phenotype in a transparent medaka modelDOI 10.21203/rs.3.rs-2103020/v1Read

A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model.Semantic proximity Read

Gene disruption of medaka (Oryzias latipes) orthologue for mammalian tissue-type transglutaminase (TG2) causes movement retardation.Semantic proximity Read

High-resolution melting curve analysis for rapid detection of mutations in a Medaka TILLING library.Semantic proximity Read

pnp4a Is the Causal Gene of the Medaka Iridophore Mutant guanineless.Semantic proximity Read

Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice.Semantic proximity Read

Transgenerational genomic instability as revealed by a somatic mutation assay using the medaka fish.Semantic proximity Read

Identification of radiation-sensitive mutants in the Medaka, Oryzias latipes.Semantic proximity Read

Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.Semantic proximity Read

A novel phenotypic marker for ATM-deficient 129S6/SvEvTac-ATMtm1Awb/J mice.Semantic proximity Read

Radiation-induced untargeted germline mutations in Japanese medaka.Semantic proximity Read

Responses of embryonic germ cells of the radiation-sensitive Medaka mutant to gamma-irradiation.Semantic proximity Read