Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.

doi:10.1016/s0306-4522(98)00117-1

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Article

Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.

Neuroscience - 1 Oct 1998

Soares H D, Morgan J I, McKinnon P J

Abstract excerpt

Ataxia-telangiectasia is a human autosomal recessive disease characterized by neurodegeneration, cancer predisposition and sensitivity to ionizing radiation. One of the earliest features of this disease is ataxia, which is thought to be attributable to a progressive cerebellar degeneration associ...

Topics

Animals
Ataxia Telangiectasia
Blotting, Northern
Brain Chemistry
Cerebellum
Ganglia, Spinal
Gene Expression Regulation, Developmental
Genes
Humans
In Situ Hybridization
Mice
Mice, Inbred Strains
Mutation
Peripheral Nervous System
Phenotype

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