Article
A novel phenotypic marker for ATM-deficient 129S6/SvEvTac-ATMtm1Awb/J mice.
Anatomical record (Hoboken, N.J. : 2007) - 1 Mar 2007
Hibma Jody C, Neufeld Daniel A, Halaby Marie-Jo, Yang Da-Qing
Abstract excerpt
Ataxia-telangiectasia (A-T) is a human autosomal recessive disorder characterized by neuronal degeneration as well as many other physiological and somatic defects. ATM (A-T, mutated), the gene mutated in A-T, encodes a 370 kDa protein kinase. ATM knockout mouse models (ATM(-/-)) show growth retar...
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