Article
A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model.
PloS one - 1 Jan 2023
Chisada Shinichi, Ohtsuka Kouki, Fujiwara Masachika, Yoshida Masao, Matsushima Satsuki, Watanabe Takashi, Karita Kanae, Ohnishi Hiroaki
Abstract excerpt
The MRE11A-RAD50-NBS1 complex activates the ataxia-telangiectasia mutated (ATM) pathway and plays a central role in genome homeostasis. The association of RAD50 mutations with disease remains unclear; hence, we adopted a medaka rad50 mutant to demonstrate the significance of RAD50 mutation in pathogenesis using the medaka as an experimental animal. A 2-base pair deletion in the rad50 gene was introduced into...
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