Article
Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity.
Nature genetics - 1 Oct 2023
Westcott Peter M K, Muyas Francesc, Hauck Haley, Smith Olivia C, Sacks Nathan J, Ely Zackery A, Jaeger Alex M, Rideout William M, Zhang Daniel, Bhutkar Arjun, Beytagh Mary C, Canner David A, Jaramillo Grissel C, Bronson Roderick T, Naranjo Santiago, Jin Abbey, Patten J J, Cruz Amanda M, Shanahan Sean-Luc, Cortes-Ciriano Isidro, Jacks Tyler
Abstract excerpt
DNA mismatch repair deficiency (MMRd) is associated with a high tumor mutational burden (TMB) and sensitivity to immune checkpoint blockade (ICB) therapy. Nevertheless, most MMRd tumors do not durably respond to ICB and critical questions remain about immunosurveillance and TMB in these tumors. In the present study, we developed autochthonous mouse models of MMRd lung and colon cancer. Surprisingly, these models...
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