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Article

Microsatellite instability-high colorectal cancer patient-derived xenograft models for cancer immunity research.

Journal of cancer research and therapeutics - 1 Jan 2000

Suto Hirotaka, Funakoshi Yohei, Nagatani Yoshiaki, Imamura Yoshinori, Toyoda Masanori, Kiyota Naomi, Matsumoto Hisayuki, Tanaka Shinwa, Takai Ryo, Hasegawa Hiroshi, Yamashita Kimihiro, Matsuda Takeru, Kakeji Yoshihiro, Minami Hironobu

Abstract excerpt

CONTEXT: There is an increasing demand for appropriate preclinical mice models for evaluating the efficacy of cancer immunotherapies. AIMS: Therefore, we established a humanized patient-derived xenograft (PDX) model using microsatellite instability-high (MSI-H) colorectal cancer (CRC) tissues and patient-derived peripheral blood mononuclear cells (PBMCs). SUBJECTS AND METHODS: The CRC tissues of patients...

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PMID: 34916366
DOI: 10.4103/jcrt.JCRT_1092_20

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