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Article

Emergence of a plasmid-borne tigecycline resistance in Klebsiella pneumoniae in Vietnam

1 Mar 2021

Abstract excerpt

Tigecycline is a last-resort antimicrobial used to treat multidrug-resistant Gram-negative bacterial infections. One of the common antimicrobial resistance mechanisms is the efflux pump system composed of membrane protein complexes to excrete xenobiotic substrates. Recently, a novel gene cluster, tmexCD1-toprJ1, encoding the resistance–nodulation–cell division (RND) efflux pump was identified on plasmids in...

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PMID: 33704044
DOI: 10.1099/jmm.0.001320

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