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Article

The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms.

Frontiers in cellular and infection microbiology - 1 Jan 2024

Jiang Chao, Yang Jie, Xiao Gang, Xiao Ning, Hu Jie, Yang Yi, Sun Zhiliang, Li Yujuan

Abstract excerpt

Tigecycline is a last-resort drug used to treat serious infections caused by multidrug-resistant bacteria. tet(X4) is a recently discovered plasmid-mediated tigecycline resistance gene that confers high-level resistance to tigecycline and other tetracyclines. Since the first discovery of tet(X4) in 2019, it has spread rapidly worldwide, and as a consequence, tigecycline has become increasingly ineffective in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39282498
DOI: 10.3389/fcimb.2024.1444031
PMCID: PMC11392914

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