Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene <i>mcr</i> in one plasmid confers transferable multidrug resistance in <i>Klebsiella pneumoniae</i>

Abstract excerpt

Tigecycline is considered one of the last-resort antimicrobials for carbapenem-resistant K. pneumoniae. Plasmid-mediated tigecycline resistance remains largely unclear. Here, by utilizing whole genome sequencing, we report a plasmid-mediated tigecycline resistance mechanism, a 6,489 bp Resistance-nodulation-division family (RND) efflux pump (tmexCD1-toprJ1 pump), that confers transferable tigecycline resistance...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antibiotic Resistance in Bacteria
• Share to Antibiotics Pharmacokinetics and Efficacy
• Share to Pharmaceutical and Antibiotic Environmental Impacts