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Article

Genomic insights into the tmexCD-toprJ: plasmid-mediated evolution, dissemination and diversity in bacterial populations.

The Journal of antimicrobial chemotherapy - 4 Mar 2026

Wan Lilan, Li Xinran, Zheng Xiaoyu, Chen Tian, Yang Yan, Chen Yong, Liu Xiong, Wang Changjun

Abstract excerpt

BACKGROUND: The plasmid-mediated tigecycline resistance gene tmexCD-toprJ has emerged in clinical and animal isolates, but its epidemiological spread and plasmid adaptation mechanisms remain unclear. METHODS: We characterized tmexCD-toprJ-carrying plasmids from the PLSDB database through comprehensive bioinformatic analyses, revealing their genetic features and potential inter-species transmission routes....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41853961
DOI: 10.1093/jac/dkag107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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