Article

AAV-mediated peripheral single chain variable fragments’ administration to reduce cerebral tau in adult P301S transgenic mice: mono- vs combination therapy

2025-02-17

Abstract excerpt

Tau is a primary target for immunotherapy in Alzheimer’s disease. Recent studies have shown the potential of anti-tau fragment antibodies in lowering pathological tau levels in vitro and in vivo . Here, we compared the effects of single-chain variable fragments (scFv) derived from the well-characterized monoclonal antibodies PHF1 and MC1. We used adeno-associated virus 1 (AAV1) to deliver scFvs to skeletal muscl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: be57e6ac-a1c7-5415-a94a-727dc2631147
DOI: 10.1101/2025.02.13.638144

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

AAV-mediated peripheral single chain variable fragments’ administration to reduce cerebral tau in adult P301S transgenic mice: mono- vs combination therapyDOI 10.1101/2025.02.13.638144Read

Anti-tau conformational scFv MC1 antibody efficiently reduces pathological tau species in adult JNPL3 mice.Semantic proximity Read

Anti-tau scFvs Targeted to the Cytoplasm or Secretory Pathway Variably Modify Pathology and Neurodegenerative PhenotypesSemantic proximity Read

Anti-Tau VHH Therapy Against PHF6: A Safe Approach to Slowing the Phenotype of Tau PathologySemantic proximity Read

Anti-tau VHH therapy against PHF6: a safe approach to slowing the phenotype of tau pathology.Semantic proximity Read

Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models.Semantic proximity Read

Virally encoded single-chain antibody fragments targeting alpha-synuclein protect against motor impairments and neuropathology in a mouse model of synucleinopathySemantic proximity Read

AAV mediated delivery of a novel anti-BACE1 VHH reduces Abeta in an Alzheimer’s disease mouse modelSemantic proximity Read

Targeted brain-specific tauopathy compromises peripheral skeletal muscle integrity and functionSemantic proximity Read

Inhibition of tau neuronal internalization using anti-tau single domain antibodiesSemantic proximity Read

AAV-mediated neuronal expression of a scFv antibody selective for Aβ oligomers protects synapses and rescues memory in Alzheimer modelsSemantic proximity Read

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.Semantic proximity Read

In Vivo Applications of Single Chain Fv (Variable Domain) (scFv) FragmentsSemantic proximity Read