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Article

Neuronally expressed anti-tau scFv prevents tauopathy-induced phenotypes in Drosophila models.

Neurobiology of disease - 1 Apr 2020

Krishnaswamy Senthilkumar, Huang Huai-Wei, Marchal Isabella S, Ryoo Hyung Don, Sigurdsson Einar M

Abstract excerpt

We have derived single-chain variable fragments (scFv) from tau antibody hybridomas and previously shown their promise as imaging diagnostic agents. Here, we examined the therapeutic potential of anti-tau scFv in transgenic Drosophila models that express in neurons wild-type (WT) human tau (htau) or the human tauopathy mutation R406W. scFv expressing flies were crossed with the tauopathy flies and analyzed....

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Identifiers

PMID: 31982516
DOI: 10.1016/j.nbd.2020.104770
PMCID: PMC7178494

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