Article

SIRT1 activity orchestrates ECM expression during hESC-chondrogenic differentiation

2020-05-12

Abstract excerpt

Epigenetic modification is a key driver of differentiation and the deacetylase Sirtuin1 (SIRT1) is an established regulator of cell function, ageing and articular cartilage homeostasis. Here we investigate the role of SIRT1 during development of chondrocytes by using human embryonic stem cells (hESCs). HESC-chondroprogenitors were treated with SIRT1 activator; SRT1720, or inhibitor; EX527, at different development...

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Literature Corpus work: be546cc5-0fc8-5f50-b1a8-1eb910e5c93f
DOI: 10.1101/2020.05.12.087957

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